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KMID : 0352519870240010539
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Korea Univercity Medical Journal
1987 Volume.24 No. 1 p.539 ~ p.548
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A Study of Angiographic Contrast Media on Renal Toxicity
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全惠廷/Jeon, Hae-Jeong
鄭元均/徐源赫/Chung, Woun-Kyun/Suh, Won-Hyuck
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Abstract
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There has been many complications after infusion of radiologic contrast materials. Acute re!ial failure has been also one of complications following use of iodinated radiographic contrast media. But, recent developments of contrast media have reduced to very low instance the renal insufficiency. following angiography.
The present study was performed to analysis prospectively the incidence of acute renal failure in 148 consecutive patients who had angiography. The angiographic studies were including 39 cases of celiac arteriography with superior mesenteric arteriography, 6 cases of cardiac angiogaphy, 40 cases of cerebral arteriography, 42 cases of femoral arteriography and 21 cases of renal angiography. There were only two incidences of renal failure following the procedure.
The contrast media were meglumine iothalamate 60%, sodium methylglucamine iothalamate 60%, sodium methylglucamine ioxitalamate 60%, sodium methylglucamine diatrizoate 76% and the dose was l.lcc/kg (CM/BW).
We studied the levels of blood urea nitrogen, serum creatinine, prior to angiography, immediately after angiography, 24 hours and 48 hours after angiography respectively.
The summarized results were as follows:
1. There was no significant change of blood urea nitrogen or serum creatinine level before and after angiography in 146 consecutive patients who were in normal renal function before angiography. But two patients who were pancreatic carcinoma and essential hypertension had been in renal insufficiency before angiography, showed renal failure after angiography.
2. There was no significant statistical difference between pre-angiography and post-angiography in the
evaluation of BUN, serum creatinine in patients, regardless of age or kinds of contrast media.
3. Renal artery and non-renal artery injection such as cerebral, cardiac, celiac artery or severity of peripheral
vascular disease did not have an effect on renal function.
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